This creamy Blueberry Cucumber Smoothie perfectly balances fruity sweetness with the crisp freshness of summer cucumbers. Ideal for a nutritious breakfast or a revitalizing snack, this low histamine smoothie is packed with antioxidants and vitamins, and goes great with a scoop of your favorite protein powder.
If you enjoy refreshing and nutritious smoothies, try my mango moringa smoothie or delicious microgreens smoothie!

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✔️ Why This Recipe is Great
Antihistamine Ingredients: This cucumber blueberry smoothie recipe is my way of easily sneaking more nutrients into my diet while still satisfying my sweet tooth.
Easy to Make: This creamy blueberry cucumber smoothie will please picky kiddos and adults alike, and it's super easy and fun to make! Add a touch of whimsy with a sprinkle of chopped nuts and seeds, or a big scoop of chia seeds.
Delicious Breakfast or Snack: whether you enjoy it fresh or from frozen, this low histamine smoothie is as quick to make as it is delicious.
🥒 Ingredients

Blueberries: whether you use fresh or frozen berries, these are the star of the show. They're also a strongly antihistamine fruit, as a rich source in mast cell-stabilizing antioxidants.
Cucumber: we use the small Persian cucumbers from the Farmer's Market, but you can use whichever type you enjoy. Maybe start with half a cucumber if it's particularly large.
Milk: this adds creaminess and balance to the creamy cucumber smoothie, covering up the mild bitterness from the other nutrient-rich ingredients. You can use water or any type of milk you tolerate, though I like either almond or coconut milk.
Honey: there are a multitude of low histamine sweeteners you can use in smoothies, but by far my favorite is manuka honey. Not only is it great for the digestive system, but manuka honey has been proven to lessen allergy symptoms, like those of histamine intolerance.
See recipe card for exact ingredients and quantities.
🍹 How to Make Blueberry Cucumber Smoothie (Step-by-Step)
Step 1) In a blender, combine the fresh blueberries, cucumber halves, and milk of your choice (image 1).

Step 2) Next add the ice cubes and honey, starting with 1 tablespoon. You can adjust the sweetness later if needed.

Step 3) Blend on high until smooth and creamy, making sure there are no chunks of cucumber remaining. Once it’s reached your desired consistency, taste the smoothie and add more honey if you prefer it sweeter. Blend again briefly to combine (image 2).

Step 4) Pour the smoothie into glasses and enjoy immediately.
🥥 Variations
- Coconut Water: Replace the regular water or milk with coconut water for a tropical twist and added hydration, though make sure you find a brand you tolerate well before trying this swap.
- Blackberry Cucumber: switch the blueberries for an equal amount of blackberries, though beware of the seeds.
- Mint Infusion: Add a small handful of fresh mint leaves for a refreshing herbal note that complements the cucumber as well as the blueberry.
- Chia Seeds: Stir in 1 to 2 tablespoons of chia seeds for added fiber and a thicker texture.
- Protein Powder: Include a scoop or two of your favorite low histamine protein powder to make it a post-workout smoothie.
🧊 Freezing and Storing
If you're not eating low histamine, you can refrigerate this smoothie with blueberries and cucumber for up to 72 hours, though after about two days it may become a bit soggy and any textural blackberry or chia seeds will soften. For a freezer smoothie, you can keep this frozen for up to 3 months without losing any of its nutritional value.
👨🏻🍳 Expert Notes & Tips
Extra Nutrients: This smoothie is incredibly versatile! You can add a big handful of baby kale for extra nutrients without altering the flavor much.
Added Thickness: If you want a thicker smoothie, consider adding a tablespoon of chia seeds or flax meal.
Make it Vegan: You can also substitute honey with maple syrup or agave nectar for a vegan option.
When to Enjoy: Enjoy this smoothie as a refreshing breakfast or a midday snack—it's perfect for warm days!
❓ What to Enjoy With a Blueberry Cucumber Smoothie
🙋 Frequently Asked Questions
Peeling the cucumber is optional. The skin contains nutrients, but if you prefer a smoother texture, you can choose to peel it.
While it's best enjoyed fresh, you can prepare the ingredients in advance and store them in the refrigerator. Blend everything just before serving for the best flavor and texture.
To make it more filling, consider adding ingredients like nut butter, chia seeds, or protein powder for added fiber and protein.
Absolutely! This smoothie is nutritious and delicious, making it a great option for kids. You can adjust the sweetness to their taste.
📖 Recipe

Blueberry Cucumber Smoothie
Equipment
- Blender
Ingredients
- 1 cup fresh blueberries about 150g
- 1 medium cucumber peeled and halved (about 300g)
- 1 cup milk of choice about 240ml – almond, cow's, oat, or any preferred milk
- 1-2 tablespoons honey about 15-30g, to taste
- 1 cup ice cubes about 150g
Instructions
- In a blender, combine the fresh blueberries, cucumber halves, and milk of your choice.
- Then add the ice cubes and honey, starting with 1 tablespoon. You can adjust the sweetness later if needed.
- Blend on high until smooth and creamy, making sure there are no chunks of cucumber remaining. Once it’s reached your desired consistency, taste the smoothie and add more honey if you prefer it sweeter. Blend again briefly to combine.
- Pour the smoothie into glasses and enjoy immediately.
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