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43 Foods That Lower Histamine (Anti Histamine Foods List)

When I began an antihistamine diet, I couldn’t have even told you what histamine is, much less why it might have been causing all this trouble for me. It was a hail mary, in all honesty, but damn did it work. Within a week I was feeling 50% better, and when you already feel like the gum scraped off the bottom of someone’s shoe, 50% better is nothing to scoff at. While I’m still sorting out the root cause(s) for my histamine issues, I’m also continuing to research anti histamine foods I can work into my diet to help bring a variety of flavors and nutrients to every meal.

So what are histamines?

Histamine is a natural inflammatory substance released by the mast cells, which are a type of white blood cell responsible for immediate reactions to perceived allergens. When your histamine level overloads in one area of the body, it leads to inflammation, which can result in food allergy symptoms and even have a cascading effect upon the body. Histidine decarboxylase (HDC) is the sole member of the histamine synthesis pathway, producing histamine out of the amino acid histidine in a one-step reaction (with Vitamin B6 as a cofactor).

This means that histamine can be produced very quickly, an evolutionary trait which is helpful for alerting you to danger, but less helpful if your immune system has begun interpreting everything as dangerous. So while mast cells are an integral part of the body’s immune response to foreign substances, sometimes they can become unstable and overreact to certain foods.

What happens when mast cells destabilize?

They release histamine (and other inflammatory substances, albeit in smaller amounts), causing an inflammatory condition known as Mast Cell Activation Syndrome (MCAS). MCAS is a type of Mast Cell Activation Disorder (MCAD), a group of immune conditions which affect the functioning of mast cells. Mastocytosis is a similar disorder, and treatment similarly involves lowering the body’s histamine load. The first step towards calming this histamine reaction is to clean up your diet, and slowly add in more anti histamine foods.

How do antihistamine foods help with histamine intolerance symptoms?

Food is really the best antihistamine for histamine intolerance, as most of us aren’t necessarily overloaded by our environment— as with traditional histamine toxicity (a.k.a. seasonal allergies)— but by our food. This goes back to the three main ways that histamine levels become problematic: ingested histamine, low DAO (diamine oxidase, which clears histamine), and histamine-liberating foods. There can be genetic contributions, but these factors most commonly arise when we consume high histamine food, DAO-blocking food, and food which releases histamine from other foods.

Anti histamine foods are all naturally low in histamine, but they also bring other histamine-clearing benefits to the table. The foods’ superpowers range from helping to stabilize mast cells to increasing DAO production or simply reversing oxidative damage from inflammation. Some of them even interrupt the making of histamine itself, by affecting volume & rate of HDC production (thereby slowing the body’s ability to produce histamine). Most of them also contain a significant amount of one or more co-factors in the production of DAO, such as vitamin B12, saturated fats, zinc, magnesium, iron, and omega-3 fats.

Anti Histamine Foods List

The antihistamine foods list below is a living document that I’ll continue to update as I discover new ingredients which may help us in our pursuit of health and happiness— you should never have to prioritize one over the other. If you’ve found this post because you’re just getting started with a low histamine diet, I recommend beginning by reading my 5-day low histamine diet plan.

Jumping into a whole new lifestyle headfirst can work for some people, but for others, adding or taking away a large variety of foods at once can send your system into a tailspin. So before adding in a bunch of foods that lower histamine, consider a three-pronged approach of: 1) removing the highest histamine foods; 2) eating more low histamine foods in their place; and 3) adding in anti histamine foods last.

All that said, below are dozens of foods with natural antihistamine properties. Because I’m a science-minded individual who loves to cook, I’ve sorted each of these natural antihistamine foods based on their function in the kitchen. Most foods have multiple reasons why they’re listed here, so I’ve done my best to link sources for further reading.

Antihistamine Herbs

  • Basil (esp. Holy Basil)
  • Cilantro
  • Dill
  • Lemongrass
  • Mint (Spearmint, Peppermint)
  • Oregano
  • Parsley
  • Rosemary
  • Sage
  • Thyme

Antihistamine Spices

  • Black Cumin (nigella sativa)
  • Caraway
  • Cardamom
  • Cumin
  • Fennel Seed
  • Garlic
  • Ginger
  • Turmeric

Antihistamine Vegetables

  • Artichoke
  • Arugula
  • Asparagus
  • Bok Choy
  • Broccoli (& Broccolini)
  • Brussels Sprouts
  • Cabbage
  • Greens (Mustard, Collard)
  • Onion
  • Radish
  • Squashes (other than pumpkin)
  • Watercress
  • Zucchini

Antihistamine Fruits

  • Apples
  • Pomegranate
  • Blueberries
  • Blackberries
  • Cherries
  • Mangoes
  • Kiwis

Other Natural Antihistamines

  • Aloe Vera (anti-inflammatory in small doses)
  • Fresh Capers (preserved in salt & rinsed before use are also ok)
  • Spirulina (inhibits histamine release)
  • Moringa (stabilizes mast cells)
  • Stinging Nettle (great for tea, or adding to smoothies in powdered form)

Whether you’re struggling with a runny nose or a leaky gut, it’s important to understand how natural antihistamines can help you heal. For those who’ve also chosen to consume your antihistamine in food form, do you have any others to add to the list?

2 Comments

  1. Great list! I slowly add things to my diet. I haven’t been able to use any herbs or spices in my cooking for about two years now, not even sea salt. I can eat dark chocolate after not being able to eat it for two years.

    I do eat asparagus, broccolini (don’t tolerate broccoli, green cabbage (but not red cabbage), and French radish (but not regular). Everything else puts me in a tailspin.

    For fruit, I can eat blueberries, blackberries, and cherries. Apples and pomegranates give me water blisters around my mouth.

    For the “other natural histamines”, I used to take aloe vera juice daily for my ulcerative colitis, but since I was taking it twice daily for over a decade, my functional medicine doc told me to take a pause for at least 6 months. Black cumin oil is something I’ve also taken in liquid form, it tastes awful, but I did notice a difference. If you can tolerate soft gels, I have used Life Extension with no issues. I open the capsule up and put it in my mouth or add to a smoothie.

    1. Thank you, Annmarie! I’m so sorry you can’t tolerate any herbs or spices right now, but dark chocolate sounds amazing. I finally ran into black cumin oil in the store just yesterday… I’ll have to spring for it and give it a try myself. Maybe hidden in a salad dressing?

      Aloe weirdly makes me very red and sensitive, which has taken a lot of sunscreen options (among other things) off the table. It always amazes me how individually people experience (ostensibly) the same ailments!

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